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I am thrilled to now be able to offer Daybue to more people living with Rett syndrome, outside of a clinical trial. Daybue is supplied as a strawberry-flavored oral solution containing 200 mg of trofinetide per mL. The dosage is determined by patient weight and can be administered orally or via gastrostomy tube. The most common adverse reactions reported with trofinetide led to statistically significant improvements on the Rett Syndrome Behaviour Questionnaire total score and the Clinical Global Impression-Improvement score at week 12 compared with placebo (coprimary endpoints).

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